A series of illustrations in a 15th century Timurid manuscript record the mi’raj, the ascent through the seven heavens by Mohammed, the Prophet of Islam. Several of the illustrations depict Bur¯aq, the fabulous creature by means of which Mohammed achieves his ascent, with distinctive features of the Amanita muscaria mushroom. A. muscaria or “fly agaric” is a psychoactive mushroom used by Siberian shamans to enter the spirit world for the purposes of conversing with spirits or diagnosing and curing disease. Using an interdisciplinary approach, the author explores the routes by which Bur¯aq could have come to be depicted in this manuscript with the characteristics of a psychoactive fungus, when any suggestion that the Prophet might have had recourse to a drug to accomplish his spirit journey would be anathema to orthodox Islam. There is no suggestion that Mohammad’s night journey (isra) or ascent (mi’raj)